AGN-191659 is an orally active RAR/RXR agonist with EC50 values of 11 nM, 23 nM, and 37 nM for RXRalpha, RARbeta, and RARgamma, respectively. AGN-191659 activates RXRalpha, RARbeta and RARgamma to induce gene transcription. AGN-191659 induces tissue transglutaminase activity, inhibits ornithine decarboxylase activity induced by tumor promoters, and suppresses chondrogenesis. AGN-191659 reverses basic fibroblast growth factor-induced endothelial cell proliferation. AGN-191659 induces hypertriglyceridemia in rat models. AGN-191659 inhibits total heparin-releasable lipase activity. AGN-191659 can be used in research related to promyelocytic leukemia and hypertriglyceridemia[1][2][3].
Molecular Weight:
368.54
CAS Number:
[156691-86-0]
Formula:
C23H28O2S
Target:
RAR/RXR
Application Notes:
MCE Product type: Reference compound
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