Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity[1].
Molecular Weight:
454.28
Purity:
99.77
CAS Number:
[2040295-03-0]
Formula:
C20H16Cl2F3N5
Target:
Apoptosis,c-Fms,c-Kit
Application Notes:
MCE Product type: Reference compound
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