Scio-323 is an orally available p38 mitogen-activated protein kinase (MAPK) inhibitor with the potential to inhibit chronic inflammatory responses associated with polyethylene particles. Scio-323s oral inhibition pattern had a minimal effect on bone formation. Scio-323 administration inhibited net bone formation after the establishment of a chronic inflammatory response to polyethylene particles. Osteoblast-like activity remained low in all cases of Scio-323 inhibition. Scio-323 failed to improve bone growth in the presence of polyethylene particles[1].
Molecular Weight:
479.54
CAS Number:
[309913-51-7]
Formula:
C27H30FN3O4
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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