CRCD2 is a small molecule NT5C2 nucleotidase inhibitor with enhanced 6-mercaptopurine cytotoxic activity. CRCD2 can effectively reverse 6-mercaptopurine resistance caused by mutations in the NT5C2 gene or non-genetic activation mechanisms. CRCD2 combined with 6-mercaptopurine can enhance its cytotoxic activity in NT5C2 wild-type leukemia, showing its potential in the treatment of acute lymphoblastic leukemia[1].
Molecular Weight:
340.40
Purity:
99.02
CAS Number:
[941185-83-7]
Formula:
C17H16N4O2S
Target:
Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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