RTI-122 is a selective, blood-brain barrier-permeable GPR88 agonist (cAMP EC50 = 11 nM), with EC50 values of 11.5 nM and 155 nM for human and mouse GPR88, respectively ([35S]GTPgammaS assay). By activating the GPR88 receptor to regulate the cAMP signaling pathway and G protein activity, RTI-122 significantly attenuates Binge-like drinking, reduces alcohol intake, and decreases alcohol-seeking motivation. RTI-122 blocks the reinstatement of alcohol-seeking behavior without affecting water or sucrose intake. RTI-122 exhibits metabolic stability in mice (T1/2 = 5.8 h) and can be used to investigate alcohol use disorder[1][2].
Molecular Weight:
491.60
CAS Number:
[3034664-39-3]
Formula:
C29H34FN3O3
Target:
GPR88
Application Notes:
MCE Product type: Reference compound1
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