RTI-122 dihydrochloride is a blood-brain barrier-permeable GPR88 agonist. RTI-122 dihydrochloride activates the G protein signaling pathway mediated by GPR88 by increasing cAMP accumulation and GTPgammaS binding activity. RTI-122 dihydrochloride attenuates binge-like drinking behavior, reduces alcohol intake, decreases operant alcohol self-administration and alcohol consumption motivation, and inhibits relapse of alcohol-seeking behavior in rodents. RTI-122 dihydrochloride is applicable to research related to alcohol use disorder[1][2].
Molecular Weight:
564.52
Purity:
99.67
Formula:
C29H36Cl2FN3O3
Target:
GPR88
Application Notes:
MCE Product type: Reference compound
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