ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM).
Molecular Weight:
449.55
Purity:
99.35
CAS Number:
[313254-51-2]
Formula:
C23H19N3O3S2
Target:
Sodium Channel
Application Notes:
MCE Product type: Reference compound
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