DNMT1/HDAC-IN-1 (compound (R)-23a) is a DNMT1/HDAC dual inhibitor (HDAC1:IC50=0.05 µM), HDAC1 is a major HDAC isoform that interacts with DNMT1 in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities[1].
Molecular Weight:
609.74
Formula:
C33H35N7O3S
Target:
DNA Methyltransferase,HDAC
Application Notes:
MCE Product type: Reference compound1
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