iNOs-IN-5 (Compound BN-4) is an inhibitor for iNOS with an IC50 of 0.1707 µM, and reduces NO levels in LPS (HT-D1056)-induced RAW264.7 cells. iNOs-IN-5 reduces the hypoxic injury stimulated ROS and lactate dehydrogenase expression, and exhibits anti-necrosis and anti-apoptosis efficacy. iNOs-IN-5 exhibits anti-cerebral ischemia and neuroprotective activities in SD rat models. iNOs-IN-5 is blood-brain barrier penetrable[1].
Molecular Weight:
365.47
CAS Number:
[3067565-40-3]
Formula:
C22H27N3O2
Target:
Apoptosis,NO Synthase
Application Notes:
Reference compound
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