ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent with IC50 values of 0.22 µM and 0.44 µM against TNBC proliferation in BT-549 cells and MDA-MB-231 cells, respectively. ZMF-24 inhibits Eukaryotic translation initiation factor 3 subunit D (EIF3D) that disrupts the energy supply of TNBC by inhibiting glycolysis and further induces profound TNBC apoptosis by stimulating persistent ER stress[1].
Molecular Weight:
567.67
Formula:
C35H37NO6
Target:
Apoptosis,Eukaryotic Initiation Factor (eIF)
Application Notes:
Reference compound
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