DD205-291 is an orally active PROTAC HPK1 degrader, with a DC50 value of 5.3 nM. DD205-291 inhibits SLP-76 phosphorylation and induces IL-2 and IFN-gamma expression (Pink: HPK1 protein ligand HY-168283, E3+linker: HY-168284, Blue: E3: HY-W115490, Black: linker: HY-W210252)[1].
Molecular Weight:
775.22
CAS Number:
[3047066-15-6]
Formula:
C38H38ClF3N10O3
Target:
MAP4K,PROTACs
Application Notes:
MCE Product type: Reference compound
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