E0924G is an orally active activator for PPARdelta with EC50 of 2.82 µM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC50 of 0.29 µM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models[1].
Molecular Weight:
232.24
Purity:
99.17
CAS Number:
[2909474-29-7]
Formula:
C12H12N2O3
Target:
PPAR
Application Notes:
MCE Product type: Reference compound
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