COX-2/15-LOX-IN-6 (Compound 5l) is the dual inhibitor for COX-2 and 15-LOX, with IC50 of 0.201 µM and 11.723 µM. COX-2/15-LOX-IN-6 inhibits the expression of PGE, TNF-alpha, IL-6 and iNOS in serum, and exhibits anti-inflammatory effect in Carrageenan (HY-125474)-induced rats edema model[1].
Molecular Weight:
552.64
Formula:
C31H28N4O4S
Target:
COX,Lipoxygenase
Application Notes:
MCE Product type: Reference compound
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