HLB-0532259, CAS [[2566733-45-5]]

Product Overview

• Article Name: HLB-0532259, CAS [[2566733-45-5]]
• Biozol Catalog Number: MCE-HY-168439
• Supplier Catalog Number: HY-168439
• Alternative Catalog Number: MCE-HY-168439-10MG,MCE-HY-168439-25MG,MCE-HY-168439-50MG,MCE-HY-168439-5MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

HLB-0532259 is a PROTAC degrader for Aurora-A and N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC50 of 20.2 nM, degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-168440), Black: linker (HY-W007957), Blue: ligand for E3 ligase Cereblon (HY-41547))

Product Properties

• Molecular Weight: 748.83
• Purity: 98.30
• CAS Number: [2566733-45-5]
• Formula: C40H44N8O7
• Target: Aurora Kinase,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound