HTR2A antagonist 1 (Compound 15f) is a HTR2A antagonist, with an IC50 of 42.79 nM. HTR2A antagonist 1 induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells via the activation of p53/p21/caspase 3 signaling. HTR2A antagonist 1 has good liver microsomal stability. HTR2A antagonist 1 can be used for the research of colorectal cancer[1].
Molecular Weight:
706.65
Formula:
C35H43Cl2F2N5O4
Target:
5-HT Receptor,Apoptosis
Application Notes:
MCE Product type: Reference compound
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