NF-kappaB/MAPK-IN-2 (compound 14) is a potent NF-kappaB and MAPK Inhibitor. NF-kappaB/MAPK-IN-2 decreases the protein expression of p-p65, p-IkappaB, p-p38, p-JNK, and p-ERK. NF-kappaB/MAPK-IN-2 reduces the LPS-induced release of TNF-alpha and IL-6. NF-kappaB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-kappaB/MAPK-IN-2 has the potential for the research of sepsis[1].
Molecular Weight:
827.06
Formula:
C49H66N2O9
Target:
NF-kappaB,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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