WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1s chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer[1][2][3][4].
Molecular Weight:
459.49
Purity:
99.88
CAS Number:
[2929223-35-6]
Formula:
C26H25N3O5
Target:
Apoptosis,SF3B1
Application Notes:
MCE Product type: Reference compound
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