PROTAC ALK degrader-3 (4B) is an orally active ALK degrader based on PROTACs, which can effectively induce persistent degradation of ALK fusion protein in Karpas 299 cells and strong inhibition of downstream pathways,IC50 is 119.33 nM. PROTAC ALK degrader-3 exhibits antitumor activity. (Structure Note: PINK, ALK Inhibitor (HY-15656), Blue, E3 (HY-W023573), Black, linker (HY-168552))[1].
Molecular Weight:
966.59
Formula:
C50H60ClN9O7S
Target:
Anaplastic lymphoma kinase (ALK),PROTACs
Application Notes:
MCE Product type: Reference compound
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