YJ9069 is a selective CDK12/CDK13 PROTAC degrader with an IC50 of 22.22 nM for in VCaP cells. CDK12/13 degradation rapidly triggers gene-length-dependent transcriptional elongation defects, leading to DNA damage and cell-cycle arrest. YJ9069 effectively inhibits proliferation in subsets of prostate cancer cells and significantly suppresses prostate tumor growth. (Pink: CDK12/CDK13 degradation agent (HY-168658), Black: Linker (HY-W015967), Blue: ligand for E3 ligase (HY-103596))[1].
Molecular Weight:
850.92
Purity:
97.63
Formula:
C46H46N10O7
Target:
CDK,DNA/RNA Synthesis,PROTACs
Application Notes:
MCE Product type: Reference compound
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