EGFR-IN-131 (compound 3a) is a potent and cross the blood-brain barrier EGFR inhibitor with an IC50 value of 272.9 nM. EGFR-IN-131 shows antiproliferative activity. EGFR-IN-131 induces apoptosis and cell cycle arrest at G0/G1 phase. EGFR-IN-131 decreases the protein expression of p-EGFR[1].
Molecular Weight:
474.55
Formula:
C26H23FN4O2S
Target:
Apoptosis,EGFR
Application Notes:
MCE Product type: Reference compound
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