EV206 is a Hsp70 binder and apoptosis inducer that binds to the N-terminal domain of Hsp70, promotes Hsp70 degradation via the ubiquitin-proteasome system, and reduces Hsp70 protein stability. EV206 induces apoptotic cell death, inhibits colony formation, and downregulates the expression of cancer stem cell-related markers in non-small cell lung cancer cells. EV206 inhibits the growth of H460 xenograft tumors in nude mice and can be used for the research of non-small cell lung cancer[1].
Molecular Weight:
329.40
Purity:
99.62
CAS Number:
[2247047-81-8]
Formula:
C21H19N3O
Target:
HSP
Application Notes:
MCE Product type: Reference compound
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