TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function[1].
Molecular Weight:
419.48
Purity:
98.83
CAS Number:
[1909225-07-5]
Formula:
C23H25N5O3
Target:
Akt,Apoptosis,PI3K,TRP Channel
Application Notes:
MCE Product type: Reference compound
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