p53 Activator 13 (compound 11) is a 6mA methyltransferase CamA inhibitor and a p53 activator. p53 Activator 13 intercalates into CamA-bound DNA via the minor groove, causing a conformational shift that moves the catalytic domain away from the DNA and elicits DNA damage response via p53 activation. p53 Activator 13 can be utilized in cancer research[1].
Molecular Weight:
573.69
Formula:
C33H35N9O
Target:
DNA Methyltransferase,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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