SIAIS562055, CAS [[3062106-15-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-168637
Supplier Catalog Number:
HY-168637
Alternative Catalog Number:
MCE-HY-168637-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
SIAIS562055 is a potent cereblon-based SOS1 PROTAC with a Kd of 95.9 nM. SIAIS562055 exhibits sustained degradation of SOS1 and inhibition of downstream ERK pathways. SIAIS562055 effectively blocked the binding of KRASG12C or KRASG12D to SOS1, with the IC50 values of 95.7 nM and 134.5 nM, respectively. SIAIS562055 exhibits potent anticancer activity. (Pink: SOS1 ligand (HY-168638), Black: linker (HY-W539874), Blue: E3 ligase ligand (HY-W076696))[1].
Molecular Weight:
918.12
CAS Number:
[3062106-15-1]
Formula:
C49H62F3N7O5S
Target:
PROTACs,Ras,SOS1
Application Notes:
MCE Product type: Reference compound
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