Microtubule inhibitor 12 (Compound 2k) is an inhibitor for microtubule polymerization with an IC50 of 22.23 µM. Microtubule inhibitor 12 arrests the cell cycle of B16-F10 at G2/M phase, induces apoptosis in B16-F10, and inhibits cell migration. Microtubule inhibitor 12 inhibits the proliferation of cancer cells B16-f10, A549, HepG2 and MCF-7, with IC50s of 0.098, 0.135, 0.109, and 0.259 µM, respectively. Microtubule inhibitor 12 exhibits antitumor efficacy in mouse model[1].
Molecular Weight:
390.44
Formula:
C22H22N4O3
Target:
Apoptosis,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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