Delta3,5-cholestadien-7-one is an oxysterol and a negative allosteric modulator of GABAA receptors. Delta3,5-cholestadien-7-one reduces GABA-induced currents in HEK cells expressing alpha1beta1gamma2 or alpha4beta3gamma2 subunit-containing GABAA receptors with IC50 values of 1.5 and 1 µM, respectively. Delta3,5-cholestadien-7-one reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons[1][2].
Molecular Weight:
382.62
Purity:
95
CAS Number:
[567-72-6]
Formula:
C27H42O
Target:
GABA Receptor
Application Notes:
MCE Product type: Natural Products
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