Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-alpha-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD, EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases[1][2][3].
Molecular Weight:
293.77
CAS Number:
[862377-51-3]
Formula:
C13H12ClN3OS
Target:
Apoptosis,RIP kinase,TNF Receptor
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
