JNK3 inhibitor-9 (Compound 24a) is a potent, selective and BBB-permeable JNK3 inhibitor with an IC50 value of 12 nM. JNK3 inhibitor-9 also potently inhibits GSK3alpha/beta (IC50s: 14 and 35 nM, respectively) involved in Tau phosphorylation. JNK3 inhibitor-9 reduces c-Jun and APP phosphorylation. JNK3 inhibitor-9 protects neurons from Abeta1-42 toxicity[1].
Molecular Weight:
457.53
Formula:
C25H27N7O2
Target:
Amyloid-beta,GSK-3,JNK
Application Notes:
MCE Product type: Reference compound1
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