Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folic acid metabolic pathway. Insecticidal agent 19 inhibits Leishmania major promastigote and amastigote with IC50 of 1.43 µM and 3.78 µM[1].
Molecular Weight:
514.87
Formula:
C26H15ClN4O6
Target:
Dihydrofolate reductase (DHFR) ,Parasite
Application Notes:
MCE Product type: Reference compound
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