KWR137 is a WRN degrader, with an IC50 of 8 nM. KWR137 exhibits good anti-proliferative activity against MSI-H cells, with a GI50 of 509 nM in SW48 cells and a GI50 of 824 µM in HCT116 cells. It also demonstrates anti-tumor growth effects in xenograft mouse models. KWR137 can be used for cancer research[1].
Molecular Weight:
710.11
Formula:
C33H31ClF3N9O4
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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