Lysosomal P-gp targeted agent 1, CAS [[3043797-88-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-168953
Supplier Catalog Number:
HY-168953
Alternative Catalog Number:
MCE-HY-168953-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Lysosomal P-gp targeted agent 1 (Compound 14) is an anti-tumor agent targeting lysosomal P-glycoprotein (Pgp). Lysosomal P-gp targeted agent 1 is selectively transported into lysosomes by overexpressed Pgp, release nitric oxide (NO) to generate reactive oxygen species (ROS), resulting in lysosomal membrane permeabilization (LMP) and inducing apoptosis. Lysosomal P-gp targeted agent 1 can overcome P-glycoprotein-mediated drug resistance and lead to cell cycle arrest, but relatively low toxicity to normal cells. Lysosomal P-gp targeted agent 1 has antitumor activity, significantly inhibits tumor volume[1].
Molecular Weight:
706.76
CAS Number:
[3043797-88-9]
Formula:
C39H34N2O9S
Target:
Apoptosis,Bcl-2 Family,Caspase,P-glycoprotein,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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