PROTAC BTK Degrader-13 (Compound 25) is the PROTAC degrader for BTK with a DC50 of 0.27 µM. PROTAC BTK Degrader-13 inhibits the activity of BTK with an IC50 of 0.44 µM, inhibits IL-2-induced T cell kinase (ITK) with an IC50 of 2.16 µM. PROTAC BTK Degrader-13 inhibits p38 MAPK signaling pathway, block the activation of the BCR (B cell receptor) signaling pathway[1]. (Pink: ligand for target protein BTK ligand 15 (HY-168965), Black: linker (HY-Y0524), Blue: ligand for E3 ligase cereblon (HY-103596))
Molecular Weight:
622.63
Formula:
C33H30N6O7
Target:
Btk,Itk,p38 MAPK,PROTACs
Application Notes:
MCE Product type: Reference compound
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