Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection[1].
Molecular Weight:
314.32
CAS Number:
[401816-26-0]
Formula:
C19H11FN4
Target:
Casein Kinase,Fungal
Application Notes:
MCE Product type: Reference compound
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