Evo312 is a dose-dependent inhibitor of protein kinase Cbeta1 (PKCbeta1) (IC50 is 117.34 nM). Evo312 induces PANC-GR (acquired gemcitabine-resistant PC cells) cell cycle arrest and apoptosis by inhibiting PKCbeta1 protein expression. Evo312 has antiproliferative effects in pancreatic cancer cells PANC-1 and PANC-GR cells with IC50 of 0.08 µM and 0.07 µM, and in human normal pancreatic ductal epithelial cells HPDE6-c7 with IC50 of 2.95 µM. Evo312 exhibits antitumor activity in a PANC-GR cell transplantation mouse model[1].
Molecular Weight:
361.39
CAS Number:
[2820245-53-0]
Formula:
C21H19N3O3
Target:
Apoptosis,PKC
Application Notes:
MCE Product type: Reference compound
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