JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity[1].
Molecular Weight:
368.36
Purity:
98.44
CAS Number:
[3056388-71-4]
Formula:
C19H17FN4O3
Target:
JNK
Application Notes:
MCE Product type: Reference compound
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