DCN1-IN-2 is a DCN1 inhibitor with an IC50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFbeta-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3[1].
Molecular Weight:
426.84
CAS Number:
[2543578-57-8]
Formula:
C18H14ClF3N4OS
Target:
TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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