SLC7A11-IN-2 (Compound 1) is an SLC7A11/xCT inhibitor. SLC7A11-IN-2 induces cell death in HeLa cells by lowering intracellular glutathione levels and increasing oxidative stress, thereby disrupting the oxidative balance within the cells, with an IC50 value of 10.23 µM. Molecular dynamics simulation analysis indicates that SLC7A11-IN-2 has a stronger binding affinity to SLC7A11 compared to Erastin (HY-15763). SLC7A11-IN-2 can be utilized in research within the field of cervical cancer[1].
Molecular Weight:
356.42
Purity:
99.80
CAS Number:
[14668-59-8]
Formula:
C19H24N4O3
Target:
Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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