WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/beta-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/beta-catenin signaling by inhibiting the enzymatic activity of TNKS2[1][2]. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 µM[3].
Molecular Weight:
521.59
Purity:
99.93
CAS Number:
[838818-26-1]
Formula:
C29H23N5O3S
Target:
PARP,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound1
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