AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ⩽0.015 µg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith[1][2].
Molecular Weight:
375.42
Purity:
99.49
CAS Number:
[620175-39-5]
Formula:
C22H21N3O3
Target:
Antibiotic,Bacterial
Application Notes:
MCE Product type: Reference compound
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