GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of GPX4 through the HSP 90 chaperone complex, reduces endogenous GPX4 expression to induce ferroptosis in HT-1080 cells, and the DC50 value is 0.08 µM (Pink: Target protein ligand (HY-153748), Blue: HSP90 ligand (HY-10212), Black: Linker (HY-W169526))[1].
Molecular Weight:
994.99
CAS Number:
[2991588-80-6]
Formula:
C48H53Cl2N13O5S
Target:
Ferroptosis,Glutathione Peroxidase,PROTACs
Application Notes:
MCE Product type: Reference compound
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