CYP3A4-IN-4 (compound delta,-3), a Ru(II) Ir(III) Conjugate, is a photoactive inhibitor of the major human drug metabolizing enzyme CYP3A4. CYP3A4-IN-4 containing the [Ru(tpy)(Me2bpy)] photocaging group showed an IC50 of 2.2 µM for inhibition of microsomal CYP3A4 under light conditions (lambdairr=530 nm, tirr=15 min). CYP3A4-IN-4 shows the phototherapeutic index (PI) for of 5.4[1].
Molecular Weight:
1656.19
Formula:
C80H61Cl3IrN11ORuS2
Target:
Cytochrome P450
Application Notes:
MCE Product type: Reference compound1
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