WS-11 is a non-covalent reversible BTK inhibitor with IC50s of 3.9 nM and 2.2 nM for wild type, C481S mutation BTK, respectively. WS-11 can form strong pi-pi interaction with PHE540 and form p-pi interaction with LYS430 within the active pocket, besides the strong hydrogen bonds[1].
Molecular Weight:
511.51
CAS Number:
[2759280-09-4]
Formula:
C26H22FN9O2
Target:
Btk
Application Notes:
MCE Product type: Reference compound1
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