SJYHJ-026 (compound 37) is a pregnane X receptor (PXR) PROTAC degrader with the DC50 of 86.6 nM and maximal degradation of 66.4%. SJYHJ-026 shows cell cytotoxic aganist SNU-C4 HiBiT-PXR KI cells with the IC50 values of 97.4 µM (24 h) and 99.5 µM (72 h) (Blue: VHL ligand HY-125845,Black: linker HY-43048,Pink: PXR inhibitor HY-169277)[1].
Molecular Weight:
1125.42
Formula:
C60H84N8O11S
Target:
Pregnane X Receptor (PXR),PROTACs
Application Notes:
MCE Product type: Reference compound1
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