BRD-K20733377 is an inhibitor for Bcl-2, and exhibits selective cytotoxicity against senescent cells, that inhibits the viability of Etoposide (HY-13629)-induced IMR-90 senescent cell with an IC50 of 10.7 µM. BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21 and KI67 in aged mouse model[1].
Molecular Weight:
430.48
Purity:
99.50
CAS Number:
[452350-43-5]
Formula:
C23H18N4O3S
Target:
Bcl-2 Family
Application Notes:
MCE Product type: Reference compound1
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