PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC50 value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280), Black: Linker (HY-43048), Blue: Ligand for E3 ligase (HY-125845)[1].
Molecular Weight:
1127.35
Formula:
C58H78N8O13S
Target:
Epigenetic Reader Domain,Pregnane X Receptor (PXR),PROTACs
Application Notes:
MCE Product type: Reference compound1
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