MD-265 is a PROTAC degrader that can break down MDM2, leading to activation of p53 in cancer cells carrying wild-type p53. MD-265 achieves complete tumor regression and improves long-term survival of mice with leukemia. (Pink: MI-1063 (HY-133754), Black: linker, Blue: Lenalidomide (HY-A0003)[1].
Molecular Weight:
921.88
CAS Number:
[2415160-21-1]
Formula:
C50H51Cl2FN6O6
Target:
MDM-2/p53,PROTACs
Application Notes:
Reference compound
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