SD-436, CAS [[2497585-50-7]]

Product Overview

• Article Name: SD-436, CAS [[2497585-50-7]]
• Biozol Catalog Number: MCE-HY-169360
• Supplier Catalog Number: HY-169360
• Alternative Catalog Number: MCE-HY-169360-10MG,MCE-HY-169360-5MG,MCE-HY-169360-1MG,MCE-HY-169360-25MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 µM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 µM (STAT5) and >10 µM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361), Blue: E3 ligase ligand (HY-43722), Black: linker (HY-147052)[1].

Product Properties

• Molecular Weight: 1248.20
• Purity: 98.27
• CAS Number: [2497585-50-7]
• Formula: C58H62F4N9O14PS
• Target: PROTACs,STAT

Application Notes

• Application Notes: Reference compound