PD-L1 degrader-2 (Compound B3) is an orally active AUTAC degrader, that degrades PD-L1 through autophagy-lysosome pathway with a DC50 of 0.5 µM. PD-L1 degrader-2 exhibits inhibitory activity against PD-1/PD-L1 interaction with an IC50 of 22.8 nM. PD-L1 degrader-2 upregulates the expressions of Atg9b, Lamp1 and Mitf, and activates the autophagy lysosome system. PD-L1 degrader- exhibits antitumor efficacy in CT26 mouse model[1]. (Pink: autophagy-lysosome activator (HY-159894), Black: linker (HY-W015088), Blue: PD-L1 ligand (HY-169365))
Molecular Weight:
780.91
Purity:
99.41
Formula:
C45H48N8O5
Target:
AUTACs,Autophagy,PD-1/PD-L1
Application Notes:
Reference compound
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