PARL-IN-2 (Compound 14) is a covalent inhibitor of the mitochondrial intramembrane protease PARL with an EC50 value of 0.16 µM. PARL-IN-2 leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-2 promotes PINK1/Parkin-dependent mitophagy[1].
Molecular Weight:
365.42
Purity:
98.63
Formula:
C22H23NO4
Target:
Mitophagy,PINK1/Parkin
Application Notes:
Reference compound
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