OICR41114 is a WDR5 PROTAC degrader with an EC50 of 40 nM. OICR41114 binds both DCAF1 and WDR5, and its binding affinity for DCAF1 is significantly enhanced in the presence of WDR5 (KD increases from 59 nM to 5 nM). OICR41114 exerts antiproliferative effects on MV4-11 cells. OICR41114 can be used for the research of acute myeloid leukemia[1].
Molecular Weight:
1475.36
Formula:
C70H83Cl2F6N9O15
Target:
PROTACs,WDR5
Application Notes:
MCE Product type: Reference compound
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